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dc.contributor.authorThomas, K.D.
dc.contributor.authorAdhikari, A.V.
dc.contributor.authorTelkar, S.
dc.contributor.authorChowdhury, I.H.
dc.contributor.authorMahmood, R.
dc.contributor.authorPal, N.K.
dc.contributor.authorRow, G.
dc.contributor.authorSumesh, E.
dc.date.accessioned2020-03-31T08:23:34Z-
dc.date.available2020-03-31T08:23:34Z-
dc.date.issued2011
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2011, Vol.46, 11, pp.5283-5292en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/11004-
dc.description.abstractThree new series of 4-hydroxy-8-trifluoromethyl-quinoline derivatives were synthesized through multi step reactions. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 5j was evidenced by X-ray crystallographic study. The newly synthesized title compounds were evaluated for their antimicrobial activities including antimycobacterial activity. Amongst the tested compounds, 5b, 5e, 5h, 5j, 6c and 7c displayed promising antimicrobial activity. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands, 5b, 5e, 5h, 5j and 6c. 2011 Elsevier Masson SAS. All rights reserved.en_US
dc.titleDesign, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agentsen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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