Please use this identifier to cite or link to this item: http://idr.nitk.ac.in/jspui/handle/123456789/11285
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dc.contributor.authorHadagalli, K.
dc.contributor.authorPanda, A.K.
dc.contributor.authorMandal, S.
dc.contributor.authorBasu, B.
dc.date.accessioned2020-03-31T08:31:03Z-
dc.date.available2020-03-31T08:31:03Z-
dc.date.issued2019
dc.identifier.citationACS Applied Bio Materials, 2019, Vol.2, 5, pp.2171-2184en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/11285-
dc.description.abstractAlthough hydroxyapatite (HA)-based porous scaffolds have been widely researched in the last three decades, the development of naturally derived biomimetic HA with a tunable elastic modulus and strength together with faster biomineralization properties has not yet been achieved. To address this specific issue, we report here a scalable biogenic synthesis approach to obtain submicron HA powders from cuttlefish bone. The marine-resource-derived HA together with different pore formers can be conventionally sintered to produce physiologically relevant scaffolds with porous architecture. Depending on pore formers, the scaffolds with a range of porosity of up to 51% with a larger range of pore sizes up to 50 ?m were fabricated. An empirical relationship between the compression strength and the elastic modulus with fractional porosity was established. A combination of moderate compressive strength (12-15 MPa) with an elastic modulus up to 1.6 GPa was obtained from cuttlefish-bone-derived HA with wheat flour as the pore former. Most importantly, the specific HA scaffold supports the faster nucleation and growth of the biomineralized apatite layer with full coverage within 3 days of incubation in simulated body fluid. More importantly, the marine-species-derived HA supported better adhesion and proliferation of murine osteoblast cells than HA sintered using powders from nonbiogenic resources. The spectrum of physical and biomineralization properties makes cuttlefish-bone-derived porous HA a new generation of implantable biomaterial for potential application in cancellous bone regeneration. 2019 American Chemical Society.en_US
dc.titleFaster Biomineralization and Tailored Mechanical Properties of Marine-Resource-Derived Hydroxyapatite Scaffolds with Tunable Interconnected Porous Architectureen_US
dc.typeArticleen_US
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