Please use this identifier to cite or link to this item: http://idr.nitk.ac.in/jspui/handle/123456789/12482
Title: Microbial transformation of bioactive natural products
Authors: Gopkumar, P.
Mugeraya, G.
Issue Date: 2010
Citation: Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2010, Vol.1, 3, pp.826-831
Abstract: In the present study, the fungal biotransformation of 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) is presented. Biocatalysis, isolation and subsequent structure elucidation of the newly transformed metabolite (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) is presented. Microbial transformation of Vasicine (I) by Aspergillus niger, Rhizopus arrhizus, Pencillium notatum and Trematus versicolor afforded (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) (100%) as the sole metabolic product. 1, 2, 3, 9-tetra hydrpyrrolo [2, 1-b] quinazolin-3-ol (I) and (-)-3-hydroxy -2, 3-dihydro pyrrolo [2, 1-b] quinazoline-9(1H)-one (II) screened for antibacterial and antifungal activity.
URI: http://idr.nitk.ac.in/jspui/handle/123456789/12482
Appears in Collections:1. Journal Articles

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