Please use this identifier to cite or link to this item: http://idr.nitk.ac.in/jspui/handle/123456789/12518
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dc.contributor.authorNechipadappu, S.K.
dc.contributor.authorTekuri, V.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2020-03-31T08:41:48Z-
dc.date.available2020-03-31T08:41:48Z-
dc.date.issued2017
dc.identifier.citationJournal of Pharmaceutical Sciences, 2017, Vol.106, 5, pp.1384-1390en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/12518-
dc.description.abstractTwo novel pharmaceutical co-crystals of anti-inflammatory drug flufenamic acid (FFA) with 2-chloro-4-nitrobenzoic acid (CNB) and ethenzamide (ETZ) have been synthesized by solvent evaporation method as well as by solvent drop-assisted grinding method. The synthesized co-crystals were characterized thoroughly by various spectroscopic methods and crystal structures were determined by single-crystal x-ray diffraction technique. In FFA-CNB co-crystal, robust supramolecular acid-acid homosynthon was observed. FFA-ETZ co-crystal is formed via robust supramolecular acid-amide heterosynthon. In FTIR spectra, a significant shift in the carbonyl stretching frequency was observed for the co-crystals due to the presence of intermolecular hydrogen bond. 1H nuclear magnetic resonance study suggests the presence of hydrogen bond in the solution state of FFA-ETZ co-crystal; however, it was absent for FFA-CNB co-crystal. Solubility study in Millipore water revealed that the solubility of FFA is increased by 2-fold when it is in the form of FFA-CNB co-crystal and no increment in the solubility of FFA was observed in FFA-ETZ co-crystal. About 5-fold increment in the solubility of FFA was observed in both the co-crystals in 0.1 N HCl (pH 1) solution. The synthesized co-crystals were found to be non-hygroscopic at ?75% relative humidity and stable for a period of 6 months at ambient temperature (?25 C). 2017 American Pharmacists Associationen_US
dc.titlePharmaceutical Co-Crystal of Flufenamic Acid: Synthesis and Characterization of Two Novel Drug-Drug Co-Crystalen_US
dc.typeArticleen_US
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