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dc.contributor.authorNechipadappu, S.K.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2020-03-31T08:45:12Z-
dc.date.available2020-03-31T08:45:12Z-
dc.date.issued2017
dc.identifier.citationJournal of Molecular Structure, 2017, Vol.1141, , pp.64-74en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13059-
dc.description.abstractSalts of common anti-inflammatory drugs mefenamic acid (MFA), tolfenamic acid (TFA) and naproxen (NPX) with various pyridine derivatives (4-amino pyridine (4AP), 4-dimethylaminopyridine (DMAP) and 2-amino pyridine (2AP)) were synthesized by crystal engineering approach based on the pKa values of API's and the salt former. All the salts were characterized systematically by various spectroscopic methods including FT-IR and 1H NMR and the crystal structure was determined by single-crystal X-ray diffraction techniques (SCXRD). DMAP salt of NPX and 2AP salts of MFA and TFA were not obtained in the salt screening experiments. All the molecular salts exhibited 1:1 molecular stoichiometry in the asymmetric unit and except NPX-2AP salt, all the molecular salts included a water molecule in the crystal lattice. Physicochemical and structural properties between drug-drug molecular salts of MFA-4AP, TFA-4AP and NPX-4AP have been evaluated and it was found that these molecular salts were found to be stable for a time period of six months at ambient condition and further hydration of molecular salts were not observed even at accelerated humid conditions (?75% RH). It was found that 4AP salts of MFA and TFA and DMAP salts of MFA and TFA are isostructural. 2017 Elsevier B.V.en_US
dc.titleStructural and physicochemical characterization of pyridine derivative salts of anti-inflammatory drugsen_US
dc.typeArticleen_US
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